Title: Faculty & research interests





Virginia E Papaioannou
Virginia E Papaioannou, PhD
Full Member

Department: Genetics and Development

HHSC 1402

Personal Website

Disease Models: Cancer, Immune Disorders

Stem Cell Categories: ES and other embryonic stem cells

Model Organisms: Rodent

Themes: Heart, Diabetes

The interest of her laboratory is in the genetic control of early mammalian development, from the first cleavage of the fertilized zygote through implantation, gastrulation, and early organogenesis. Her lab makes use of mouse embryonic stem cells to produce mutations by genetic engineering. In addition, two projects in the lab relate directly to stem cells. One is the derivation of human stem cell lines from clinically dead human embryos obtained from in-vitro fertilization centers. The second is testing the potential of mouse embryo pancreatic stem cell/precursors in the treatment of type 1 diabetes using a mouse model.


Begum, S., Chen, W., Herold, K. C. and Papaioannou, V. E.
Remission of type diabetes following anti-CD3 antibody treatment and transplantation of embryonic pancreatic precursors. Endocrinology 150(10):4512020. (2009)

Chen, W., Begum, S., Opare-Addo, L., Garyu, J. Gibbons, T. F., Bothwell, A. L., Papaioannou, V. E., and Herold, K. C.
Promotion of ?-cell differentiation in pancreatic precursor cells by adult islet cells. Endocrinology 150:570-9. (2009)

Gavrilov, S., Papaioannou, V. E., and Landry, D. W.
Alternative strategies for the derivation of human embryonic stem cell lines and the role of dead embryos. Current Stem Cell Research & Therapy. 4:81-86. (2009)

Gavrilov, S., Prosser, R. W., Khalid, I., Macdonald, J., Sauer, M. V., Landry, D. W. and Papaioannou, V. E.
Non-viable human embryos as a source of viable cells for embryonic stem cell derivation. Reproductive BioMedicine Online 18:301-8. (2009)

Wardle, F. and Papaioannou, V. E.
Teasing out T-box targets in early mesoderm. Current Opinions in Genetics and Development 18:418-425. (2008)

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