Title: Faculty & research interests

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Thomas M Jessell
Thomas M Jessell, PhD
Claire Tow Professor
Full Member

Department: Neuroscience
Biochemistry and Molecular Biophysics

HHSC-10
212- 305-1531 
tmj1@columbia.edu


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Disease Models:

Stem Cell Categories:

Model Organisms: Rodent

Themes: Brain, Neurodegeneration

Tom Jessell is Claire Tow Professor in the Departments of Neuroscience and Biochemistry and Molecular Biophysics at Columbia University. He is also an Investigator of the Howard Hughes Medical Institute and a co-Director of the Columbia/Kavli Institute for Brain Science. Jessell's research has examined the cellular and molecular mechanisms that control the assembly and function of the spinal motor system. His work has defined how the diverse neuronal elements that form sensory-motor circuits acquire their identity, how neuronal identity directs the formation of selective synaptic connections, and how the precision of network wiring controls refined motor skills such as locomotion. Jessell is a Fellow of the Royal Society, a Foreign Associate of the US National Academy of Sciences, and was a co-recipient of the 2008 Kavli Prize in Neuroscience



Publications:

Ciatto, C., Bahna, F., Zampieri, N., VanSteenhouse, H.C., Ranscht, B., Katsamba, P., Ahlsen, G., Posy, S., Vendome, J., Jessell, T.M., Honig, B., and Shapiro, L.
T-cadherin structures reveal a novel cadherin adhesive binding mechanism. Nature Structural Biology 17:339-47. (2010)

Peljto, M., Dasen. J.S., Mazzoni, E.O., Jessell, T.M., and Wichterle, H.
Functional diversity of ESC-derived motor neuron subtypes reveled through intraspinal transplantation. Cell Stem Cell 7:355-66. (2010)

Hantman, A.W. and Jessell, T.M.
Clarke’s column neurons as the focus of a corollary discharge circuit. Nature Neuroscience 13:1233-39. (2010)

Lek, M., Dias, J.M., Marklund, U., Uhde, C.W., Kurdija, S., Lei, Q., Sussel, L., Rubenstein, J. L., Matise, M.P., Arnold, H-H, Jessell, T.M., and Ericson, J.
A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning. Development. 137:4051-60. (2010)

Grillner, S., and Jessell, T.M.
Measured motion: searching for simplicity in spinal locomotor networks Current Opinion in Neurobiology 19:572-86. (2009)

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