Title: Faculty & research interests

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FACULTY PROFILE

Timothy H Bestor, PhD
Professor
Full Member

Department: Genetics and Development


212-305-5331
thb12@columbia.edu


Disease Models:

Stem Cell Categories: ES cells/embryonic cells

Model Organisms: Mouse, Human

Themes: Stem Cell Biology, Cancer



The interest of Dr. Bestor's laboratory is focused on the mechanisms that underlie non-Mendelian inheritance and the roles of genomic methylation patterns in transposon silencing and genomic imprinting. Stem cells have very efficient systems that silence and methylate newly integrated DNA, especially retroviral DNA. They are also interested in the abnormalities of genomic methylation patterns that are seen in breast cancer. They found that stem cells have an inefficient decatenation checkpoint that causes them to enter anaphase with entangled chromosomes, which leads to the high frequency of chromosome aberrations that are common in embryonic stem cells.

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