Title: Faculty & research interests

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Stephen P Goff
Stephen P Goff, Ph.D
Higgins Professor of Biochemistry and Molecular Biophysics
Full Member

Department: Biochemistry and Molecular Biophysics
Microbiology and Immunology

HHSC 1310c
212-305-3794
spg1@columbia.edu


Personal Website

Disease Models: Cancer, Hematological Diseases

Stem Cell Categories: ES and other embryonic stem cells

Model Organisms: Human, Rodent

Themes: Stem Cell Biology

The Goff laboratory is interested in the replication of a simple retrovirus, the Moloney murine leukemia virus, and the interaction of the virus with the host. The ultimate goal of the research is to determine the roles of each of the viral proteins in the complex life cycle, and to identify the impact of these proteins on host cellular machinery. The work is expanding our understanding of the viruses and their gene products; and perhaps more importantly, is uncovering new aspects of cell biology that are exploited by the retroviruses to drive their replication. These viral and cellular functions are likely to provide new targets for antiviral intervention, and thus treatments for retroviral diseases.



Publications:

Hogg, J.R., and Goff, S.P. (2010)
Upf1 senses 3’UTR length to potentiate mRNA decay Cell 143:379-389. (2010)

Wolf, D., and Goff, S.P. (2009)
Embryonic stem cells use ZFP809 to silence retroviral DNAs. Nature 458:1201-1204. (2009)

Valente, S.T., Gilmartin, G.M., Venkataraman, K., and Goff, S.P. (2009)
HIV-1 mRNA 3' end processing is distinctively regulated by eIF3f, CDK11, and splice factor 9G8. Mol. Cell 36:279-289. (2009)

Naghavi, M.H., Valente, S., Hatziiouannou, T., de los Santos, K., Wen, Y., Mott, C., Gundersen, G.G., and Goff, S.P.(2007)
Moesin regulates stable microtubule formation and limits retroviral infection in cultured cells. EMBO J. 26:41-52. (2007)

Wolf, D., and Goff, S.P. (2007)
mediates primer binding site-targeted silencing of murine leukemia virus in embryonic cells. Cell 131:46-57. (2007)

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