Title: Faculty & research interests

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Serge  Przedborski
Serge Przedborski, MD, PhD
Page and William Black Professor of Neurology
Full Member

Department: Neurology
Pathology and Cell Biology

P&S 5-420
212-305-1091
sp30@columbia.edu


Personal Website

Disease Models: Neurodegenerative Diseases

Stem Cell Categories: ES and other embryonic stem cells, iPS cells

Model Organisms: Human, Rodent

Themes: Neurodegeneration

Dr. Przedborski's laboratory interests focus on the molecular and cellular biology of neurodegenerative disorders such as Parkinson's disease (PD) and Amyotrophic Lateral Sclerosis (ALS). Ongoing research aims at understanding the contributions of cell-autonomous and non cell-autonomous mechanisms to neurodegeneration using both toxic and genetic experimental models of PD and ALS. In keeping with this goal, how alterations in mitochondrial biology, especially of mitochondrial dynamics and mitophagy, provoke degeneration of specific subpopulations of neurons is one of the main areas of research in the Przedborski laboratory. To what extent and by which mechanisms do non-neuronal cells, like microglia and astrocytes, participate in the demise of neurons in neurodegenerative disorders, such as PD and ALS, represent a second main line of research in this laboratory.



Publications:

Vives-Bauza C, Zhou C, Huang Y, Cui M, de Vries RL, Kim J, May J, Tocilescu MA, Liu W, Ko HS, Magrané J, Moore DJ, Dawson VL, Grailhe R, Dawson TM, Li C, Tieu K, Przedborski S.
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc Natl Acad Sci U S A. 107:378-83. (2010)

Li Y, Liu W, Oo TF, Wang L, Tang Y, Jackson-Lewis V, Zhou C, Geghman K,Bogdanov M, Przedborski S, Beal MF, Burke RE, Li C.
Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat Neurosci. 12:826-8. (2009)

Zhou C, Huang Y, Shao Y, May J, Prou D, Perier C, Dauer W, Schon EA, Przedborski S.
The kinase domain of mitochondrial PINK1 faces the cytoplasm. Proc Natl Acad Sci U S A. 105:12022-7. (2008)

Nagai M, Re DB, Nagata T, Chalazonitis A, Jessell TM, Wichterle H, Przedborski S.
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. Nat Neurosci. 10:615-22. (2007)

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