Title: Faculty & research interests

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Stuart J Firestein, PhD
Professor and Chair
Full Member

Department: Biological Sciences

923 Fairchild, MC 2438
212-854-4531
sjf24@columbia.edu


Personal Website

Disease Models: Neurodegenerative Diseases, Sensory Disorders

Stem Cell Categories: Adult stem cells

Model Organisms: Human, Rodent

Themes: Brain, Stem Cell Biology

We are concerned with the molecular and physiological mechanisms that allow us and other animals to detect and discriminate a wide variety and large number of odor molecules in the environment. We take the olfactory system also as an excellent model system for investigating questions such as : molecular recognition, signal transduction, regulation of gene expression, axon guidance and targeting; local circuit function; higher order encoding of complex stimuli (i.e. odor blends).



Publications:

Brann, J. and firestein , S. (2010)
Regeneration of new neurons is preserved in aged Vomeronasal Epithelia. J. Neurosci. 30(46):15686-15694. (2010)

Miller, A.M., Maurer, L.R., Zou, D.J.,Firestein, S., Greer, C.A.(2010)
Axon fasciculation in the developing olfactory nerve. Neural. Dev. 19:5:20:. (2010)

Valley, M.T., Mullen, T.R.,Schultz, L.C., Sagdullaev, B.T. and firestein, S. (2009)
Ablation of mouse adult neurogenesis alters olfactory bulb structure and olfactory fear conditioning. Front. Neurogenesis 1:3. doi:10.3389:. (2009)

Zou, D.J., Chesler, A., and Firestein, S.(2009)
How the olfactory bulb got its glomeruli: a just so story? Nat.Rev.Neurosci. 10(8):611-8. (2009)

Le Pichon, C.E., Valley, M.T., Polymenidou, M., Chesler, A.T., Sagdullaev, BT and Firestein, S. (2009)
Olfactory behavior and physiology are disrupted in prion protein knockout mice. Nature Neurosci Jan, 12(1):60-9. (2009)

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