FACULTY PROFILE

Stephen G Emerson, MD, PhD
Clyde Wu Professor of Immunology and Medicine
Director, Herbet Irving Comprehensive Cancer Center
Full Member

Department: Herbert Irving Comprehensive Cancer Center

ICRC 201
212-851-4846
semerson@columbia.edu

Disease Models: Hematological Diseases, Immune Disorders

Stem Cell Categories: Adult stem cells, Cancer stem cells

Model Organisms: Human, Rodent

Themes: Cancer, Blood

Dr. Emerson’s laboratory studies the transcriptional regulation of hematopoietic stem cell proliferation, self-renewal and differentiation. NF-Y, the inducible transcriptional regulator of Hox-X4 genes, telomerase, and bmi-1 is a major focus of the laboratory, as is the orphan nuclear hormone receptor nur77, which he studies along with Professor Jenni Punt. Within the context of HSC engraftment, Dr. Emerson’s laboratory also studies immune inputs into HSC proliferation, including the effects of IFNs and other products of activated T lymphocytes in the context of graft-versus-host disease

Publications:

Bungartz , B., Land H., Emerson, S.G.
NF-Y is a Key Regulator of Hematopoietic Stem Cell (HSC) regulatory genes and is Essential for Cycling but not Quiescent HSCs. Blood 119:1380-1389. (2012.)

Reshef, R., Luger, S.M., Hexner, E.O., Loren, A.W., Frey, N.V., Nasta, S.D., Goldstein, S.C. Stadtmauer, E.A. Smith, J., Bailey, S., Mick, R., Heitjan, D.F., Emerson, S.G., Hoxie, J.A., Vonderheide, R.H., Porter,D.L.
Prevention of Graft-versus-Host Disease by Blocking Lymphocyte Chemotaxis. NEJM, In Press, :. (2012.)

Zhang, Y. Sandy, A.R, Wang, J., Kato, K., He, S., Tran, I., Shan, G.T., Friedman, A., Hexner, E., Emerson, S.G., Pear, W.S., Maillard, I.
Notch signaling is a critical regulator of allogeneic T cell responses mediating graft-versus-host disease. Blood. 177:299-308. (2011)

Kato, K., Cui, S., Kuick, R., Mineishi, S., Hexner, E., Ferrara, J.L.M., Marquez, V.E., Emerson, S.G.,and Zhang, Y.
CD8+ Effector T Cells Proliferate and Persist Upon Chronic Exposure to Alloantigens through Reactivation of Stem Cell Transcriptional Programs. Biol Blood Marr Transpl, 16:755-771. (2010)

Domashenko, A.D., Danet-Desnoyers, G., Aron, A., Carroll, M.P., Emerson, S.G.
TAT-mediated transduction of NF-Ya peptide induces the ex vivo proliferation and engraftment potential of human hematopoietic progenitor cells. Blood 116:2676-2683. (2010)