Title: Faculty & research interests

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Richard B. Vallee
Richard B. Vallee, PhD
Professor
Director, Division of Cell and Molecular Biology

Full Member

Department: Pathology and Cell Biology

P&S 15-409
212-342-0546
rv2025@columbia.edu


Personal Website

Disease Models: Congenital Disorders, Neurodegenerative Diseases

Stem Cell Categories: Tissue progenitors

Model Organisms: Rodent

Themes: Brain

We are interested in the role of motor proteins in neuronal function and brain development. Using shRNAs and other reagents we are investigating the mechanism involved in neuronal migration. A particular interest is the mechanism underlying lissencephaly, which we are approaching using a combination of live imaging and in vitro biochemical and biophysic methods. We are pursuing a 2-motor model for interkinetic nuclear migration. We are also interested in the contribution of motor protein mutations to neurodegenerative disease.



Publications:

*McKenney, R. J., *Vershinin, M., Kunwar, A., +Vallee R. B., and +Gross, S. P. (*Co-first and +co-senior authors.)
LIS1 and NudE induce a persistent dynein force-producing state Cell 141:304-14. (2010)

*Ori-McKenney, K. M.., *Xu, J., +Gross, S. P., and +Vallee, R. B.
A Cytoplasmic Dynein Tail Mutation Impairs Motor Processivity Nature Cell Biol. 12:1228-34. (2010)

*Tsai, J.-T., *Lian, W.-N., Kemal, S., Kriegstein, A., and Vallee, R. B.
Kinesin 3 and Cytoplasmic Ddynein Mediate Interkinetic Nuclear Migration in Neural Stem Cells. Nature Neurosci. 13:1463-71. (2010)

Wang, X., Tsai, J.-W., Lian, W.-N, Imai, J. H., Vallee, R. B., and Shi, S.-H.
Asymmetric centrosome inheritance maintains neural progenitors in the neocortex. Nature 461:947-55. (2009)

Bremner, K. H., Scherer, J., Yi, J., Vershinin, M., Gross, S. P., and Vallee, R. B
Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit. Cell Host Microbe 6:523-35. (2009)

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