Title: Faculty & research interests

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Richard S Mann, PhD
Higgins Professor
Full Member

Department: Biochemistry and Molecular Biophysics

HHSC 1104
212-305-7731
rsm10@columbia.edu


Personal Website

Disease Models: Neurological Diseases, Sensory Disorders

Stem Cell Categories: Adult stem cells, Tissue progenitors

Model Organisms: Invertebrate

Themes: Stem Cell Biology

I carried out my Ph.D. work at M.I.T., studying murine retroviruses with David Baltimore. I began working on Drosophila development as a postdoc at Stanford University, with David Hogness. Since establishing my lab at Columbia University in 1990, I have mentored ~14 Ph.D. students and ~10 postdoctoral research fellows, who have continued with their own careers in biomedical science. Since 1990, my lab has been studying several aspects of Drosophila development, including gene regulation, Hox gene function, cell proliferation, and cell-cell signaling in the legs and other appendages. More recently, we have begun to study the development of the motor neurons that innervate the adult legs in the fly. Our focus has been on characterizing the neural stem cells (neuroblasts) that give rise to these neurons, and the combinatorial transcription factor code that gives each motor neuron its unique characteristics. In parallel, we have begun to develop and use behavioral assays to study the function of the motor circuit that is used for motor coordination as flies walk.



Publications:

Joshi, R., Sun, L., and Mann, RS
Dissecting the functional specificities of two Hox proteins Genes Dev. 24(14):1533-45. (2010)

Peng, W., Slattery, M. and Mann RS.
Transcription factor choice in the Hippo signaling pathway: homothorax and yorkie regulation of the microRNA bantam in the progenitor domain of the Drosophila eye imaginal disc. Genes Dev 23(19):2307-19. (2009)

Rohs, R., West, S., Sosinsky, A., Liu, P. Mann, RS, and Honig, B.
The role of DNA shape in protein-DNA recognition. Nature 461(7268):1248-53. (2009)

Baek M, Mann RS
Lineage and birth date specify motor neuron targeting and dendritic architecture in adult Drosophila. J Neurosci. 29(21):6904-16.. (2009)

Estella, C., McKay, D., and Mann, R.S.
Direct integrations of Wingless, Decapentaplegic, and autoregulatory inputs into Distalless during Drosophila leg development. Dev. Cell 14:86-96. (2008)

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