Title: Faculty & research interests

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Rudolph L Leibel
Rudolph L Leibel, MD
Professor of Pediatrics and Medicine
Christopher J. Murphy Memorial Professor of Diabetes Research
Co-Director, Naomi Berrie Diabetes Center

Full Member

Department: Pediatrics-Molecular Genetics

RB 620A
212-851-5315
rl232@columbia.edu


Personal Website

Disease Models: Metabolic Diseases, Endocrinological Diseases

Stem Cell Categories: ES and other embryonic stem cells, iPS cells

Model Organisms: Human, Rodent

Themes: Diabetes, Internal Organs

) Dr. Leibel is Christopher J. Murphy Professor of Diabetes Research, Professor of Pediatrics and Medicine at Columbia University Medical Center, and Head of the Division of Molecular Genetics in the Department of Pediatrics. He is also Co-Director of the Naomi Berrie Diabetes Center and Executive Director of the Berrie Program in Cellular Therapies of Diabetes, Co-Director of the New York Obesity Research Center and the Columbia University Diabetes and Endocrinology Research Center. The latter two are NIH-funded Centers. Dr. Leibel has worked in obesity research for over 25 years. His research has related to adipose tissue biochemistry and cellular physiology, the molecular genetics of control of body weight in rodents and humans, the bioenergetics of body weight regulation in humans and the role of leptin in these processes, and the molecular genetics of type 2 diabetes. His recent work includes the use of human stem cells to elucidate the molecular/developmental processes related to diabetes and obesity He is a member of the Institute of Medicine of the National Academy of Sciences, and has served as a member of the Federal Advisory Council for NIDDK and as an Associate Editor of the Journal of Clinical Investigation. His research is supported by the NIH, ADA, the New York State Stem Cell Science Program, the Russell Berrie and Helmsley Foundations, and AstraZeneca.



Publications:

Carmody JS, Wan P, Accili D, Zeltser LM, Leibel RL.
Respective Contributions of Maternal Insulin Resistance and Diet to Metabolic and Hypothalamic Phenotypes of Progeny. Obesity. 19(3):492-9. (2011)

Stratigopoulos G, Leduc CA, Cremona ML, Chung WK, Leibel RL.
Cut-like homeobox 1(CUX1) regulates expression of the fat mass and obesity-associated (FTO) and retinitis pigmentosa gtpase regulator interacting protein-1 like (RPGRIPIL) genes, and co-ordinates leptin receptor signaling. J Biol Chem. 286(3):2155-70. (2011)

Goldsmith RL, Joanisse DR, Gallagher D, Pavlovich KH, Shamoon EL, Leibel RL, Rosenbaum M.
Effects of experimental weight perturbation on skeletal muscle work efficiency, fuel utilization, and biochemistry in human subjects. Am J Physiol Regul Integr Comp Physiol. 298:R79-88. (2010)

1. Maehr R, Chen S, Snitow M, Ludwig T, Yagasaki L, Goland R, Leibel, RL, Melton, DA.
Generation of pluripotent stem cells from patients with type 1 diabetes. Proc Natl Acad Sci U S A. 106(37):15768-73. (2009)

Bromberg, Y., Overton, J, Vaisse, C, Leibel, RL, Rost, B.
In silico mutagenesis: a case study of the Melanocortin 4 Receptor. FASEB Journal. 23(9):3059-69. (2009)

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