Title: Faculty & research interests

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Peter D Canoll
Peter D Canoll, MD, PhD
Associate Professor of Clinical
Full Member

Department: Pathology and Cell Biology

ICRC Room 1001
212-851-4632
pc561@columbia.edu


Personal Website

Disease Models: Cancer, Neurological Diseases

Stem Cell Categories: Adult stem cells, Cancer stem cells

Model Organisms: Human, Rodent

Themes: Brain, Cancer

Glioblastoma is the most common and most malignant form of primary brain tumors. Dr. Canoll's lab has shown that human glioblastomas contain distinct populations of progenitor-like and stem-like cells. Using rodent models they have also shown that retroviral delivery of growth factors (PDGF) into adult progenitors will drive the formation of glioblastoma-like tumors. These tumors are composed of a mixture of retrovirus infected cells and uninfected (recruited) progenitors that are stimulated to proliferate via paracrine PDGF signaling. These results reveal the robust proliferative and self-renewing capacity of adult glial progenitors and suggest that these cells can contribute to glioma formation in 2 ways; 1) as potential cells of origin and 2) as a reactive component of the tumor environment. They are also using cre mediated deletion of tumor suppressor genes (PTEN and P53) to test the effects of these genetic alteration on the tumorigenic potential of adult progenitors. They are using these models to study the cellular mechanisms of progenitor cell and glioma cell migration and to test effects of targeted therapy on glioma growth and progenitor cell recruitment.



Publications:

Canoll, P., and Goldman J.E.(2008)
The interface between Glial progenitors and Gliomas. Acta Neuropathologica 116(5):465-77. (208)

David, C., Chen, M., Assanah, M.C., Canoll, P., and Manley, J.L.(2010)
HnRNP proteins controlled by c-Myc deregulate Pyruvate Kinase mRNA splicing in cancer Nature 463:364-368. (2010)

Assanah, M.C., Suzuki, S.O., Chen, A., Bruce, J.N., Goldman J.E., Canoll, P. (2009)
PDGF simulates the massive expansion of glial progenitors in the neonatal forebrain. Glia 57:1835-47. (2009)

Beadle, C., Assanah, M.C., Monzo, P.,Vallee, R., Rosenfeld, S.S.,and Canoll, P. (2008)
The Role of Myosin II in Glioma invasion of the brain. Molecular Biology of the Cell 19(8):3357-68. (2008)

Assanah, M., Lockhead, R., Ogden, A., Bruce J.,Goldman, J., Canoll, P.(2006)
Glial progenitors in adult white matter are driven to form malignant gliomas by PDGF expressing retroviruses. The Journal of Neuroscience 26(25):6781-90. (2006)

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