Title: Faculty & research interests

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Megan  Sykes
Megan Sykes, MD
Michael J. Friedlander Professor of Medicine and Professor of Microbiology & Immunology and Surgical
Director, Columbia Center for Translational Immunology, Columbia University College of Physicians an
Director of Research, Transplant Initiative, NewYork-Presbyterian Hospital

Full Member

Department: Medicine
Microbiology and Immunology

PH 17-111
212-305-3647
megan.sykes@columbia.edu


Personal Website

Disease Models: Immune Disorders, Transplantation

Stem Cell Categories: Adult stem cells

Model Organisms: Human, Rodent

Themes: Cancer, Blood

Our research is in the areas of hematopoietic cell transplantation, achievement of graft-versus-leukemia effects without GVHD, organ allograft tolerance induction and xenotransplantation. My research program aims to utilize bone marrow transplantation as immunotherapy to achieve graft-versus-tumor effects while avoiding the common complication of such transplants, graft-versus-host disease. Our laboratory studies in this area have led to novel approaches that have been evaluated in clinical trials. Another major area has been to utilize bone marrow transplantation for the induction of transplantation tolerance, both to organs from the same species (allografts) and from other species (xenografts). Our laboratory has worked toward the development of clinically feasible, non-toxic methods of re-educating the T cell, B cell and NK cell components of the immune system to accept allografts and xenografts without requiring long-term immunosuppressive therapy. Our work has also extended into the area of xenogeneic thymic transplantation as an approach to tolerance induction, and into the mechanisms by which non-myeloablative induction of mixed chimerism reverses the autoimmunity of Type 1 diabetes.



Publications:

Fehr T, Lucas C, Kurtz J, Onoe T, Zhao G, Hogan T, Vallot C, Rao A and Sykes M.
A CD8 T cell-intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo. Blood 115:1280-7. (2010)

Onoe T, Kalscheuer H, Chittenden M, Zhao G, Yang YG, Sykes M.
Homeostatic expansion and phenotypic conversion of human T cells depend on peripheral interactions with APCs. J Immunol. 184(12):6756-65. (2010)

Saito TI, Li H, Sykes M.
Invariant natural killer T cells are required for antitumor responses induced by host-versus-graft responses. J. Immunol. 185(4):2099-105. (2010)

Kawai T, Cosimi AB, Spitzer TR, Tolkoff-Rubin N, Suthanthiran M, Saidman S, Shaffer J, Preffer F, Ding R, Sharma V, Fishman J, Dey BR, Ko D, Hertl M, Goes N, Wong W, Williams W, Colvin RB, Sykes M, and Sachs DH.
HLA-mismatched renal transplantation without maintenance immunosupression. New Engl. J. Med. 358(4):353-61. (2008)

Zhao Y, Swenson K, Sergio JJ, Arn JS, Sachs DH, Sykes M.
Skin graft tolerance across a discordant xenogeneic barrier. Nat. Med. 2(11):1211-1216. (1996)

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