In my laboratory, current research focuses on studying adult neurogenesis and angiogenesis in the human brain. Adult neurogenesis is a mechanism of structural plasticity occurring in mammals including humans, which is necessary for learning and coping, shows adaptation to environment conditions and a significant response to medications. My research focuses on studying stem cells and their progeny in the human adult brain in the context of psychiatric, neurodevelopmental and neurodegenerative disorders. I am quantifying stem cells, cells at different stages of maturation on the neuronal and glial lineage and angiogenesis in the human autopsy brain. I am assessing the impact of psychiatric disorders, age, stress and psychopharmacologic treatment on hippocampal neuroplasticity. I am studying trophic factors expression in correlation with levels of angiogenesis and neurogenesis in the human hippocampus.
Boldrini M, Mann JJ.
Depression and Suicide. , Elsevier,, , CA, USA (2013 )
Boldrini M, Santiago AN, Hen R, Dwork AJ, Rosoklija GB, Tamir H, Arango V Mann JJ.
Hippocampal granule neuron number and dentate gyrus volume in antidepressant-treated and untreated major depression. Neuropsychopharmacology. Jan 7. doi: 10.1038/npp.2013.5. [Epub ahead of print]:. (2013 )
Boldrini M, Hen R, Underwood MD, Rosoklija GB, Dwork AJ, Mann JJ, Arango V.
Hippocampal Angiogenesis and Progenitor Cell Proliferation are Increased with Antidepressant Use in Major Depression. Biol Psychiatry Oct 1;72(7) Epub 2012 May 30:562-71.. (2012)
Boldrini, M,Arango, V.
Antidepressants, age and neuroprogenitors. Neuropsychopharmacology Reviews 35:351-352. (2010)
Boldrini, M, Underwood, M.D.,Hen, R., Rosoklija, G.B., Dwork, A.J., Mann, J.J., Arango, V.
Antidepressants increase neural progenitor cells in the human hippocampus. Neuropsychopharmacology 34(11):2376-2389. (2009)