Title: Faculty & research interests

QUICK FIND




ADVANCED SEARCH



ALPHABETICAL
LIST OF MEMBERS

FACULTY PROFILE

Laura A Johnston, PhD
Associate Professor
Full Member

Department: Genetics and Development

HHSC 704
212-305-1688
lj180@columbia.edu


Personal Website

Disease Models: Cancer, Trauma/Injury

Stem Cell Categories: Germ cells, Tissue progenitors

Model Organisms: Invertebrate

Themes: Cancer, Stem Cell Biology



Dr. Johnston's research goal is to understand how developing organs grow and ultimately cease growth. Using the simple genetic model organism Drosophila, and utilizing strategies that allow manipulation of growth in living, growing animals their studies attempt to define the organ-intrinsic growth regulatory program in molecular terms. Much of their work addresses how a cell's growth status is communicated to its neighbors during organ development. One process, cell competition, allows cells to rapidly sense and respond to growth changes in their immediate environment. Recent work from her lab indicates that cells in competition also use mechanisms to cooperate with their neighbors, ensuring optimal organ fitness. These processes provide plasticity to growing organs, and we are addressing their importance in normal growth and during regeneration.

bottom rounded