Title: Faculty & research interests

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Lori G Sussel
Lori G Sussel, PhD
Associate Professor
Full Member

Department: Genetics and Development

RB 607B
212-851-5115
lgs2@columbia.edu


Personal Website

Disease Models: Endocrinological Diseases, Metabolic Diseases

Stem Cell Categories: ES and other embryonic stem cells, Tissue progenitors

Model Organisms: Rodent

Themes: Diabetes, Internal Organs

Research in the Sussel laboratory uses mice as a model system to identify the gene regulatory networks underlying vertebrate pancreas development. We believe that understanding the development of the pancreas and the regulation of islet lineage formation will not only advance our abilities to produce functional beta cells for diabetes treatments, but can serve as a paradigm for understanding fundamental mechanisms of organogenesis. The approach we take integrates molecular techniques with mouse genetics to study the development and differentiation of the pancreas and its constituent cell types. These studies have successfully identified key transcription factors that are essential for beta cell formation, maturation and function. Furthermore, they have led to the identification of a novel endocrine cell type within mouse and human islets. Our findings have clarified many of the regulatory events associated with the production of functional islet cells and have revealed novel lineage relationships that exist between the islet cell populations.



Publications:

Gu, C.Y., Stein, G., Goebbels, S., Hörnberg, H., Nave, K., Herrera, P., White, P., Kaestner, K.H., Sussel, L.* and Lee, J.E. . (* Corresponding author)
Pancreatic beta cells require NeuroD to achieve and maintain functional maturity. Cell Metabolism 11:298-310. (2010)

Anderson, K., Solomon, K., Becker, T., Torres, C., Newgard, C, Wright, CV, Hagman, J. and Sussel L
Cooperative Transcriptional Regulation of the Essential Pancreatic islet gene NeuroD1 (Beta2) by Nkx2.2 and Neurogenin 3. JBC 284:31236-31248. (2009)

Desai, S., Pugh-Bernard, A.E., McCoy, E., Doyle, M.J. and Sussel, L.
Nkx2.2 regulates cell fate choice in the enteroendocrine cell lineages of the intestine. Developmental biology 313,:58-66. (2008)

Doyle, M.J, Loomis, Z. L. and Sussel, L.
Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet. Development 134:515-523. (2007)

Prado, C.L., Pugh-Bernard, A.E., Elghazi, L., Sosa-Pineda, B., and Sussel, L.
Ghrelin cells replace insulin producing beta cells in two mouse models of pancreas development. PNAS , 101:2924-2929.. (2004)

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