Title: Faculty & research interests

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Kang  Liu
Kang Liu, PhD
Assistant Professor
Full Member

Department: Microbiology and Immunology

HHSC 1306
212-305-0839
kl2529@columbia.edu


Personal Website

Disease Models: Immune Disorders

Stem Cell Categories: Adult stem cells

Model Organisms: Rodent

Themes: Blood

Hematopoietic stem cells differentiate into multiple lineages of lymphoid and myeloid cells that collaboratively enable functional versatility of immune system. Among them, dendritic cells (DCs) are specialized antigen presenting cells (APCs) and essential mediators of tolerance and immunity. Two closely related myeloid lineages with distinct roles in innate and adaptive immunity, i.e. monocyte and plasmacytoid DC lineages, branch off along the DC developmental pathway in the bone marrow. Dr. Liu is investigating the molecular mechanisms regulating divergence between monocyte and DC lineages in the steady state and under viral infection. In parallel, we are studying development, homeostasis and function of cDCs in non-lymphoid organs, such as a cDC population at the “gates� to the central nervous system.



Publications:

Liu K, Nussenzweig MC
Development and homeostasis of dendritic cells. Eur J Immunol. 40(8):2099-102. (2010)

Liu, K. and Nussenzweig, M.C.
Origin and development of dendritic cells. Immunol. Rev. 234:45-54. (2010)

Ginhoux, F., Liu, K., Helft, J., Bogunovic, M., Greter, M., Hashimoto, D., Price, J., Yin, N., Bromberg, J., Lira, S.A., Stanley, E.R., Nussenzweig, M. and Merad, M.
The origin and development of nonlymphoid tissue CD103+ DCs. J. Exp. Med. 206:3115-3130. (2009)

Darrasse-Jeze, G., Deroubaix, S., Mouquet, H., Victoria, G., Eisenreich, T., Yao, K., Rudensky, A., Liu, K. and Nussenzweig, M.C.
Feedback of regulatory T cell homeostasis by dendritic cells in vivo. J. Exp. Med. 206:1853-62. (2009)

Liu, K., Victora, G.D., Schwickert, T.A., Guermonprez, P., Meredith, M.M., Yao, K., Chu, F.F., Randolph, G.J., Rudensky, A.Y. and Nussenzweig, M.
In vivo analysis of dendritic cell development and homeostasis. Science 324:392-397. (2009)

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