Title: Faculty & research interests

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James E Goldman
James E Goldman, MD, PhD
Professor of pathology and Cell Biology
Director, Division of Neuropathology

Full Member

Department: Pathology and Cell Biology
Psychiatry

P&S 15-405
212-305-3554
jeg5@columbia.edu


Disease Models: Neurodegenerative Diseases, Neurological Diseases

Stem Cell Categories: neural, Adult stem cells, Tissue progenitors

Model Organisms: Human, Rodent

Themes: Brain

Our lab is working to understand environmental and lineage control of neuronal and glial fates in the developing CNS. Using viral gene transfer, transgenics, live slice imaging, and culture systems, we are defining the migration of precursor cells from germinal zones of the perinatal rodent forebrain and cerebellum, and the development of these precursors into neurons and glia. We are also interested in how these precursors can be altered to mimic the continued proliferation and migration seen in glial brain tumors. Our laboratory also studies the population of cycling precursor cells in the adult CNS to understand their fates under normal and pathological situations. For example, cycling precursors in adult white matter can differentiate into myelinating oligodendrocytes after demyelination. We have identified of a set of genes characteristic of pre-myelinating oligodendrocyte precursors in the adult brain and are using this information to illuminate molecular mechanisms of remyelination in demyelinating diseases. Our laboratory is also studying Alexander disease, a degenerative disorder of white matter caused by mutations in the astrocyte intermediate filament protein, GFAP. We have found that the intracellular accumulation of mutant GFAP leads to upregulation of cell stress pathways and alterations in astrocyte function that may cause the death of oligodendrocytes and neurons.



Publications:

Tang, G., Der Perng, M., Wilk, S., Quinlan, R., and Goldman, J.E. (2010)
Oligomers of mutant GFAP inhibit the proteasome system in Alexander disease astrocytes, and the small heat shock protein, alpha B-crystallin, reverses the inhibition, J Biol. Chem. 285:10777-10785. (2010)

Mela, A., and Goldman, J.E. (2009)
The tetraspanin, KAI1/CD82, is expressed by late-lineage oligodendrocyte precursors and may function to restrict precursor migration and promote oligodendrocyte differentiation and myelination. J. Neurosci 29:11172-81. (2009)

Lin, G., Mela, A., Guilfoyle, E.M., and Goldman J.E. (2009)
Neonatal and adult O4+ oligodendrocyte progenitors display different growth factor responses and different gene expression patterns. J. Neurosci res 3390-3402:87. (2009)

Lin, G., and Goldman, J.E. (2009)
Characterization of an FGF-responsive astrocyte precursor from the postnatal forebrain. Glia 57:592-603. (2009)

Ivkovic, S., Canoll, P.,and Goldman, J.E. (2008)
Constitutive EGFR signaling leads to glial progenitor hyperplasia in postnatal white matter. J. Neurosci. 28:914-922. (2008)

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