Dr. Snoeck was trained as clinical hematologist, with a focus on bone marrow transplantation, and from that clinical interest developed a research program in hematopoietic stem cell biology, more specifically mechanisms regulating stem cell renewal and underlying quantitative genetic variation in the behavior of hematopoietic stem cells among inbred mouse strains. Expansion of this program into directed differentiation of ES and iPS cells into thymic epithelial cells arose from the desire to attempt to alleviate post-bone marrow transplantation immune deficiency, caused, among others, by defective T cell reconstitution. In addition, through these studies into the development of anterior foregut endoderm from ES and iPS cells, the lab also focuses on the generation of lung tissue from pluripotent cells.
Green, M., Snoeck, HW.
Novel approaches for immune reconstitution and adaptive immune modeling with human pluripotent stem cells. BMC Medicine 9:51. (2011)
Avagyan, S., Aguilo, F., Kamezaki, K.,and Snoeck, HW.
Quantitative trait mapping reveals a regulatory axis involving peroxisome proliferator-activated receptors, PRDM16, transforming growth factor-2 and FLT3 in hematopoiesis. Blood (in press) :. (2011)
Green, M., Chen, A., Nostro, M.C., d’Souza, S., Schaniel, C., Lemischka, I.R., Gouon-Evans, V., Keller, G., and Snoeck HW.
Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells. Nat. Biotechnol. 29:267-272. (2011)
Aguilo, F., Avagyan, S., Labar, A., Sevilla, A., Lee, DF., Kumar, P., Lemischka, I.R., Zhou, B.Y., and Snoeck, HW.
Prdm16 is a physiological regulator of hematopoietic stem cells. Blood (in press) :. (2011)
Yvan-Charvet, L., Pagler, T., Gautier, E.L., Avagyan, S., Siry, R.L., Han, S., Welch, C.L., Wang, N., Randolph, G.J., Snoeck, HW., Tall, A.R.
ATP binding cassette transporters and HDL suppress hematopoietic stem cell proliferation. Science 328:1989-1993. (2010)