Title: Faculty & research interests





Hiroshi Mitsumoto, MD
Wesley J. Howe Professor of Neurology
Director, The Eleanor and Lou Gehrig MDA/ALS Research Center

Associate Member

Department: Neurology


Personal Website

Disease Models:

Stem Cell Categories:

Model Organisms:

Themes: Neurodegeneration

Dr. Mitsumoto's research interests involve patient care as he works to find the disease mechanisms, cause and treatment for ALS. He is participating in a number of clinical trials in ALS and helping his colleagues to lead major clinical trials funded by NIH. He is interested in genetic environmental epidemiology, oxidative stress markers, and environmental stressors in ALS. He has directed the comprehensive study of objective diagnostic markers for upper and lower motor neuron dysfunction, and is now developing a new MRS method to detect in situ glutamate and glutathione changes. Dr. Mitsumoto is also interested in developing a new clinically meaningful changes scale from assessments made by patients, family caregivers and physicians. Such a scale is essential to interpret clinical improvement in therapeutic trials. He is participating in the nuclear transfer of ALS patient fibroblasts to fertilized human oocyte as a way to generate the patient's ES cells. He has also initiated projects on skin-derived stem cells. Dr. Mitsumoto is now conducting a large multicenter study of oxidative stress in patients with ALS and primary lateral sclerosis (PLS). He is planning to hold an International ALS Conference: To Promote Clinical Research to Find the Pathogenesis and Cause of ALS in the fall of 2011.


Gordon PH, Goetz RR, Rabkin JG, Dalton K, McElhiney M, Hays AP, Marder K, Stern Y, Mitsumoto H.
A prospective cohort study of neuropsychological test performance in ALS. Amyotroph Lateral Scler 11:312-320. (2010)

Gilbert RM, Fahn S, Mitsumoto H, Rowland LP.
Parkinsonism and motor neuron diseases: twenty-seven patients with diverse overlap syndromes. Mov Disord 25:1868-75. (2010)

Mitsumoto H and Rabkin JG.
Palliative care for patients with amyotrophic lateral sclerosis: ‚Äúprepare for the worst and hope for the best.‚Ä?, McGraw Hill, , , (2010)

Rabkin JG, Albert SM, Rowland LP, Mitsumoto H.
How common is depression among ALS caregivers? A longitudinal study. Amyotroph Lateral Scler 10:448-55. (2009)

Kim WK, Liu X, Sandner J, Pasmantier M, Andrews J, Rowland LP, Mitsumoto H.
Study of 962 patients indicates progressive muscular atrophy is a form of ALS. Neurology 73:1686-92. (2009)

bottom rounded