Title: Faculty & research interests

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Helen H Lu
Helen H Lu, PhD
Associate Professor of Biomedical Engineering
Associate Professor of Dental and Craniofacial Bioengineering

Full Member

Department: Biomedical Engineering
Dental Medicine

351 Engineering Terrace
212-854-4071
hl2053@columbia.edu


Personal Website

Disease Models: Musculoskeletal Disorders

Stem Cell Categories: Adult stem cells, iPS cells

Model Organisms: Human, Rodent

Themes: Bioengineering, Bone and Teeth

Research in Dr. Lu's lab centers on understanding how the biological interface between different types of connective tissues (e.g. bone and ligament or tendon) are formed and maintained in the body, and more importantly, how to re-establish these distinct tissue-to-tissue boundaries post injury. Their working hypothesis is that heterotypic cellular communications play a significant role in the regeneration and homeostasis of distinct skeletal tissue boundaries. Specifically, they have been characterizing the structure-function relationship at the native soft tissue-bone interface, as well as applying these insights to the design of tissue engineering-based methods and technologies which can facilitate biological fixation and enable the integration of orthopaedic soft tissue graft with bone. Additionally, they are investigating the role of heterotypic cellular interactions in the mechanism regulating interface maintenance as well as stem cell-mediated repair of these distinct tissue-to-tissue boundaries.



Publications:

Moffat KL, Wang IE, Rodeo SA and Lu HH
Orthopaedic interface tissue engineering for the biological fixation of soft tissue grafts. Clinics in Sports Medicine 28(1):15-76. (2009)

Moffat KL, Spalazzi JP, Doty SB, Levine WN and Lu HH.
Novel nanofiber based scaffold for rotator cuff repair and augmentation Tissue Engineering 15(1):115-126. (2008)

Lu HH, Vo JM, Lin J, Shin S, Cozin M, Tsay R and Landesberg R.
Controlled delivery of growth factors derived from platelet-rich plasma for bone formation. Journal of Biomedical Materials Research A 86A(4):1128-1136. (2008)

Spalazzi JP, Vyner MC, Jacobs MT, Moffat KL, Rich CG and Lu HH.
Mechano-active scaffold induces tendon remodeling and expression of fibrocartilage markers Clinical Orthopaedics and Related Research 466(8):1938-1948. (2008)

Moffat KL, Sun WA, Pena PE, Chahine NO, Doty SB, Ateshian GA, Hung CT, and Lu HH.
Characterization of the structure-function relationship at the ligament-to-bone interface Proceedings of the National Academy of Sciences 105(23):7947-7952. (2008)

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