Title: Faculty & research interests





Gary  Struhl
Gary Struhl, PhD
Investigator, Howard Hughes Medical Institute

Full Member

Department: Genetics and Development

HHSC 1118

Personal Website

Disease Models: Cancer

Stem Cell Categories: Tissue progenitors

Model Organisms: Invertebrate

Themes: Stem Cell Biology

Much of our work has been concerned with understanding how the global body pattern is organized by the anterior, posterior, and terminal determinant systems laid down in the egg during oogenesis. More recently, we have begun to examine spatial signaling which controls growth and patterning in cells giving rise to the adult appendages. In both cases, the general approach has been to identify putative signaling molecules, as well as receptors and other cellular components involved in responding to these signals, and then to manipulate these gene products by altering their structures or patterns of expression in vivo. Such experiments indicate in molecular terms what spatial information is, how it arises, and how it governs pattern.


Casal J, Lawrence PA, Struhl G.
Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity. Development. 133(22):4561-4572.. (2006)

Perez-Garijo A, Martin FA, Struhl G, Morata G.
Dpp signaling and the induction of neoplastic tumors by caspase-inhibited apoptotic cells in Drosophila. Proc Natl Acad Sci U S A 102(49):17664-17669. (2005)

Wang W, Struhl G
Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila. Development 132(12):2883-94. (2005)

Chen CM, Strapps W, Tomlinson A, Struhl G.
Evidence that the cysteine-rich domain of Drosophila Frizzled family receptors is dispensable for transducing Wingless. Proc Natl Acad Sci U S A . 101(45):15961-16966. (2004)

Wang W, Struhl G
Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch. Development 131(21):5367-5380. (2004)

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