Title: Faculty & research interests

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Gerard  Karsenty
Gerard Karsenty, MD, PhD
Professor and Chairman
Full Member

Department: Genetics and Development
Medicine

1602A HHSC
212-305-6398
gk2172@columbia.edu


Personal Website

Disease Models: Endocrinological Diseases, Metabolic Diseases

Stem Cell Categories: Adult stem cells

Model Organisms: Human, Rodent

Themes: Diabetes

Gerard Karsenty received his M.D. and Ph.D. from the University of Paris, France and completed his post-doctoral training at the University of Texas MD Anderson Cancer Center in 1990. His laboratory has studied every aspect of skeletal biology ranging from cell differentiation to function. The overarching assumption of his current work is that the appearance of bone during evolution has changed profoundly the physiology of animals because of the energetic cost that bone modeling and remodeling entails. Thus his group has explored in the last 10 years the hypothesis that the control of bone mass and energy metabolism must be coordinated and that this coordination is done in large part by hormones like leptin and osteocalcin that appear during evolution with bone. His lab has explored through genetic and molecular means every aspect of this hypothesis. At the same time a expanding his research the Karsenty lab is exploring whether there are additional connections between bone physiology and the function of other organs such as fertility. Dr. Karsenty is the 2010 recipient of the Richard Lounsberry Award given jointly by the National Academy of Science (USA) and the French Academy of Science and the Jacobaeus Prize given by the NovoNordisk Foundation (Denmark).



Publications:

Yadav, V.K., Balaji, S., Suresh, P.S., Liu, X.S., Li, Z., Guo, E.X., Mann, J.J., Balapure, A.K., Gershon, M.D., Medhamurthy, R., Vidal, M., Karsenty, G., and Ducy, P. (2010)
Inhibition of gut-derived serotonin synthesis: a potential bone anabolic treatment. Nat Medicine 16:308-12. (2010)

Ferron, M, Wei, J., Yoshizawa, T., Del Fattore, A., De Pinho, R.A., Teti, A., Ducy, P. and Karsenty, G.(2010)
Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell 142:296-308. (2010)

Yadav, V.K., Oury, F., Suda, N., Liu, Z-W., Gao, X-B., Confavreux, C., Klemenhagen, K.C., Tanaka, K.F., Gingrich, J.A., Guo, E., Tecott, L.H., Mann, J.J., Hen, R., Horvath, T.L. and Karsenty G.(2009)
A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite and energy expenditure Cell 138(5):976-89. (2009)

Yadav, V.K., Ryu, J.H., Suda, N., Tanaka, K., Gingrich, J., Schutz, G., Glorieux, F.H., Insogna, K., Mann, J,J., Hen, R., Ducy, P. and Karsenty, G.(2008)
Lrp5 control bone mass by inhibiting serotonin synthesis in the duodenum. Cell 135:825-37. (2008)

Lee, N.K., Sowa, H., Hinoi, E., Ferron, M., Ahn, J.D., Confavreux, C., Dacquin, R., Mee, P.J., McKee, M., Jung, D.Y., Zhang, Z., Kim, J.K., Mauvais-Jarvis, F., Ducy, P., and Karsenty, G.(2007)
Endocrine regulation of energy metabolism by the skeleton. Cell 130:456-69. (2007)

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