Title: Faculty & research interests

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Fiona K Doetsch
Fiona K Doetsch, PhD
Associate Professor
Full Member

Department: Pathology and Cell Biology
Neuroscience
Neurology

P&S 14, 401-H
212 342 5633
fkd2101@columbia.edu


Personal Website

Disease Models: Cancer, Neurodegenerative Diseases

Stem Cell Categories: Adult stem cells, Tissue progenitors

Model Organisms: Rodent

Themes: Brain, Stem Cell Biology

Stem cells residing in germinal regions in the adult brain continuously generate large numbers of neurons, which become integrated into neural circuits. In mammals, new neurons are incorporated into areas important for olfaction and for memory formation. The addition of thousands of neurons each day provides a powerful means of sculpting brain circuitry. Although the functional consequences of adult neurogenesis are not yet understood, much has been learned about their cellular lineage. We have found that the stem cells for in vivo adult neurogenesis are a subset of astrocytes. The identification of the in vivo stem cells as astrocytes raises the exciting possibility that other brain astrocytes may be latent stem cells. We are using a variety of molecular, cellular and genetic approaches to discover the regulation, lineage relationships, diversity and function of stem cells in the adult mammalian brain. The biology of neural stem cells and their in vivo niche is key to understanding brain repair and neural pathologies, including tumors, and may also lead to insights in other stem cell fields.



Publications:

Cheng, L., Pastrana, E., Tavazoie, M., and Doetsch, F.
miR-124 regulates adult neurogenesis in the SVZ stem cell niche Nature Neuroscience 12:399-408. (2009)

Pastrana, E., Cheng, L., and Doetsch, F.
Simultaneous prospective purification of adult subventricular zone neural stem cells and their progeny. PNAS 106:6387-92. (2009)

Tavazoie, M., Van der veken L., Silva-Vargas, V., Louissaint, M., Colonna, L., Zaidi, b., Garcia-Verdugo, J.M.,and Doetsch, F.
A specialized vascular niche for adult neural stem cells. Cell Stem Cell 3:279-88. (2008)

Doetsch, F.,Petreanu, L.,Callie, I., Garcia-Verdugo, J.M., and Alvarez-Buylla,A.
EGF converts transit ampilfying neurogenic precursors in the adult brain into multipotent stem cells. Neuron 36:1021-34. (2002)

Doetsch, F., Callie, I., Lim, D., Garcia-Verdugo, J.M.,and Alvarez-Buylla,A.
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 97:703-716. (1999)

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