Title: Faculty & research interests

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David M Owens
David M Owens, PhD
Assistant Professor
Full Member

Department: Dermatology
Pathology and Cell Biology


212-851-4544
do2112@columbia.edu


Personal Website

Disease Models: Cancer (Squamous Cell carcinoma), Skin Diseases

Stem Cell Categories: Adult stem cells

Model Organisms: Human, Mouse

Themes: Skin, Cancer



The overall focus of Dr. Owens' research is to determine the contributions of stem cells and differentiated cells to the development of cutaneous squamous cancer. Four specific areas of investigation include: i) identifying and characterizing subpopulations of clonogenic, multipotent stem cells in normal and neoplastic skin epithelium in order to determine the significance of target cell phenotype in the formation of epithelial squamous cancers; ii) defining the mechanism of how aberrant expression of the α6β4 integrin receptor can disrupt TGF-β mediated growth inhibition thereby altering the epidermal tumor microenvironment and stimulating tumor cell progression and metastasis; iii) defining the requirement for cell surface proteins that regulate immune tolerance in the metastasis and invasion of malignant epithelial keratinocytes, and iv) investigating the role of biosynthetic pathways in epithelial keratinocyte proliferation and carcinogenesis.

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