Title: Faculty & research interests

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Chaolin  Zhang
Chaolin Zhang, PhD
Assistant Professor of Systems Biology in the Department of Biochemistry and Molecular Biophysics
Assistant Professor in Joint Centers for Systems Biology

Full Member

Department: Biochemistry and Molecular Biophysics
Motor Neuron Center

P&S 4-448
212-327-7354
cz2294@columbia.edu


Disease Models: Bioinformatics, Neurodegenerative Diseases

Stem Cell Categories: ES and other embryonic stem cells, iPS cells

Model Organisms: Human, Rodent

Themes: Brain, Neurodegeneration

We study how proteins and RNA interact to form regulatory networks in the mammalian nervous system at the mechanistic and systems level. We are particularly interested in better understanding the roles of these post-transcriptional networks in the mammalian complexity manifested in evolutionary-developmental (evo-devo) processes, such as the specification of neuronal cell types, and in neuronal disorders. To approach these aims, we use a combination of biochemistry, molecular biology, and high-throughput quantitative and integrative approaches in mice as well as in in vitro systems.



Publications:

Darnell, J.C., Van Driesche, S.J., Zhang, C., Hung, K.Y.S., Mele, A., Fraser, C.E., Stone, E.F., Chen, C., Fak, J.J., Chi, S.W., Licatalosi, D.D., Richter, J.D., Darnell, R.B.,
FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism. Cell 146:1:247-26. (2011)

Zhang, C. †, Darnell, R.B. (†co-corresponding authors)
Mapping in vivo protein-RNA interactions at single-nucleotide resolution from HITS-CLIP data. Nat. Biotech. 29:607-614. (2011)

Zhang, C. †, Frias, M.A., Mele, A., Ruggiu, M., Eom, T., Marney, C.B., Wang, H., Licatalosi, D.D., Fak, J.J., Darnell, R.B†. (†co-corresponding authors)
Integrative modeling defines the Nova splicing-regulatory network and its combinatorial controls. Science. 329:439-443 . (2010)

Castle, J.C., Zhang, C., Shah, J.K., Kulkarni, A.V., Cooper, T.A., Johnson, J.M.
. Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines. Nature Genet. 40:1416-1425. (2008)

Zhang, C.*, Zhang, Z.*, Castle, J., Sun, S., Johnson, J., Krainer, A.R. and Zhang, M.Q. (*joint first authors)
Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2. Genes Dev. 22:2550-2563 . (2008)

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