Title: Faculty & research interests

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Clark T Hung
Clark T Hung, PhD
Professor
Full Member

Department: Biomedical Engineering

351 Engineering Terrace, MC8904
212-854-6542
cth6@columbia.edu


Personal Website

Disease Models: Musculoskeletal Disorders, Trauma/Injury

Stem Cell Categories: Adult stem cells, Tissue progenitors

Model Organisms: Human

Themes: Bioengineering

) Brief bio outlining research interest (200 words):Dr. Hung has been pursuing multidisciplinary research using state-of-the-art biological and engineering tools to perform studies to investigate physical effects (e.g., cell deformation, fluid flow effects, electric fields, osmotic pressure) on cells and tissues, and the incorporation of these forces in strategies to develop functional tissue substitutes (such as for articular cartilage) of clinical relevance. Cell sources include chondrocytes, mesenchymal stem cells and more recently induced pluripotent stem cells. An understanding of the effects of physical forces on cells is important in the development of effective tissue replacements that mimic or restore normal tissue structure function in orthopaedic and other load-bearing tissues of the body. Such studies may lead to strategies aimed at alleviating the most prevalent and chronic problems afflicting the musculoskeletal system such as arthritis, and problems related to sports and occupational injuries.



Publications:

Grayson, W.L., Bhumiratana, S., Chao, G.P.H., Hung C.T., Vunjak-Novakovic, G. (2010)
Spatial regulation of human mesenchymal stem cell differentiation in engineered osteochondral constructs: effects of pre-differentiation, soluble factors and medium perfusion. Osteoarthritis Cartilage 18(5):714-723. (2010)

Huang, A.H., hung, C.T., and mauck, R.L. (2010)
Functional cartilage tissue engineering with adult stem cells: current status and future directions in Stem Cells for Regenerative Medicine, Science Publisher, , , (2010)

Ng, K.W., Lima, E.G., Bian, L., O'Connor, C.J., Jayabalan, P.S., Stoker, A.M., Kuroki, K., Cook,C.R., Ateshian, G.A., Cook, J.L., Hung, C.T. (2010)
Passaged adult chondrocytes can form engineered cartilage with functional mechanical properties: A canine model. Tissue Engineering Part A 16(3):1041-1051. (2010)

Bian, L., Fong, J.V., Lima, E.G., Stoker, A.M., Ateshian, G.A., Cook, J.L. and Hung, C.T. (2010)
Dynamic mechanical loading enhances functional properties of tissue engineered cartilage using mature canine chondrocytes Tissue Engineering Part A 16(5):1781-1790. (2010)

Hung, C.T.(2009)
One breath closer to making engineered tissues a clinical reality. Cell Stem Cell 4(1):5-6. (2009)

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