Title: Faculty & research interests

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Christopher R Jacobs, PhD
Associate Professor
Full Member

Department: Biomedical Engineering


212-854-4460
crj2111@columbia.edu


Personal Website

Disease Models:

Stem Cell Categories: Mesenchymal

Model Organisms: Mouse

Themes: Bioengineering



Dr. Jacobs is broadly interested in the molecular mechanisms whereby cells sense and respond to changes in their mechanical environment. His is specifically interested in this question in the context of bone. He investigates how existing osteoblasts and osteocytes are regulated by their mechanical environment, as well as how mechanics affects the proliferation and differentiation of bone cell progenitors and marrow derived mesenchymal stem cells. His group has recently focused on structural molecules as potential sites of molecular mechanosensing including the actin cytoskeleton and focal adhesions. They also have shown that the cell's primary cilia act as mechanical sensors and as a center for the integration of biophysical and biochemical stimuli. Preliminary data addressing the role of primary cilia in the differentiation of mesenchymal stem cells into osteoblasts, chondrocytes, and adipocytes have been collected. Dr. Jacobs lab utilizes cell culture approaches as well as tissue specific conditional knockouts in mice.

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