Title: Faculty & research interests

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Cory T Abate-Shen
Cory T Abate-Shen, PhD
Michael and Stella Chernow Professor of Urologic Sciences (in Urology)
Full Member

Department: Urology
Pathology and Cell Biology
Herbert Irving Comprehensive Cancer Center

ICRC Rm 321
212- 851- 4735
cabateshen@columbia.edu


Personal Website

Disease Models: Cancer, Musculoskeletal Disorders

Stem Cell Categories:

Model Organisms:

Themes: Cancer

The long-standing interest of our laboratory is to understand the relationship between the processes that control normal development and those that lead to cancer. A major focus of our research has been the analyses of vertebrate homeobox genes, which encode transcriptional regulatory proteins that are essential developmental regulators and are frequently deregulated in cancer. Over the years, our laboratory has taken a multi-disciplinary approach to investigate how homeobox genes regulate gene transcription during development, as well as how their aberrant expression contributes to tumorigenesis. This work has led to the generation of new mouse models of human cancer, which have provided important insights regarding mechanisms of tumorigenesis, as well as pre-clinical models for chemoprevention and chemotherapy. In parallel, our investigations of the functions of homeobox genes in development have provided insights regarding the fundamental problem of how homeoprotein transcription factors achieve target recognition in vivo during murine embryogenesis and how homeobox genes regulate stem cell function in development.



Publications:

Puzio-Kuter, A.M., Castillo-Martin,M., Kinkade, C. W., Wang, X., Shen, T.H., Matos, T., Sun, Y. Shen, M. M., Cordon-Cardo, C., and Abate-Shen, C.
Inactivation of p53 and Pten promotes invasive bladder cancer. Genes Dev. 23:675-680. (2009)

Wang, X, Kruithof-de Julio, M., Economides, KD, Walker, D., Yu. H., Halili, MV, Hu, Y, Price, S, Abate-Shen, C., and Michael M. Shen. (2009)
A luminal epithelial stem cell that is a cell of origin for prostate cancer. Nature 461:495-500. (2009)

Kinkade, C.W., Castillo-Martin, M., Puzio-Kuter, A., Yan, J., Foster, T.H., Gao, H., Sun,, Y., Ouyang, X., Gerald, W.L., Cordon-Cardo, C., and Abate-Shen, C.
Targeting Akt/TOR and Erk MAPK signaling inhibits hormone-refractory prostate cancer in a pre-clinical mouse model. Journal of Clinical Investigations 118:3051-3064. (2008)

Lee, H., Quinn, J., Prasanth, K.V., Swiss, V.A., Economides, K.E., Camacho, M.M., Spector, D.L, and Abate-Shen, C.
PIAS1 confers DNA-binding specificity on the MSX1 homeoprotein. Genes Dev. 20:784-794. (2006)

Lee, H., Habas, R., and Abate-Shen, C.
Msx1 cooperates with histone H1b for inhibition of transcription and myogenesis. Science 304:1675-1678. (2004)

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