Title: Faculty & research interests

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Boris V Reizis
Boris V Reizis, PhD
Associate Professor
Full Member

Department: Microbiology and Immunology

HHSC 1510
212-305-5793
bvr2101@columbia.edu


Personal Website

Disease Models: Hematological Diseases, Immune Disorders

Stem Cell Categories: Adult stem cells, Cancer stem cells

Model Organisms: Human, Rodent

Themes: Blood, Stem Cell Biology

Stem cells manifest a unique capacity to differentiate into various cell types while maintaining their own number in an undifferentiated state. The unique property of continuous self-renewal is shared among different stem cell types, including pluripotent embryonic stem cells and adult tissue-specific stem cells such as hematopoietic stem cells. Dr. Reizis is investigating the mechanisms regulating stem cell self-renewal, including potential common mechanisms shared by embryonic and adult stem cells, as well as by cancer stem cells. In parallel, we are studying the molecular basis of hematopoietic stem cell differentiation to certain blood cell types, such as interferon-producing plasmacytoid dendritic cells.



Publications:

Sathaliyawala, T., O'Gorman, W.E., Greter, M., Bogunovic, M., Konjufca, V., Hou, Z.E., Nolan, G.P., Miller, M.J., Merad, M. and Reizis B.
Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling Immunity 33(4):597-606. (2010)

Arenzana, T.L., Smith-Raska, M.R. and Reizis, B.
Transcription factor Zfx controls BCR-induced proliferation and survival of B lymphocytes. Blood 113:5857-67. (2009)

Cisse, B., Caton, M.L., Lehner, M., Maeda, T., Scheu, S., Locksley, R., Holmberg, D., Zweier, C., den Hollander, N.S., Kant, S.G., Holter, W., Rauch, A., Zhuang, Y. and Reizis B.
Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell 135:37-48. (2008)

Ghosh, H.S., Cisse, B., Bunin, A., Lewis, K.L. and Reizis B.
Continuous expression of the transcription factor E2-2 maintains the cell fate of mature plasmacytoid dendritic cells. Immunity 33(6):905-16. (2007)

Galan-Caridad, J.M., Harel, S., Arenzana, T.L., Hou, Z.E., Doetsch, F.K., Mirny, L.A. and Reizis, B.
Zfx controls the self-renewal of embryonic and hematopoietic stem cells. Cell 129:345-57. (2007)

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