Title: Faculty & research interests

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FACULTY PROFILE

Brent R Stockwell
Brent R Stockwell, PhD
Associate Professor
Full Member

Department: Biological Sciences
Chemistry

614 Fairchild, MC 2406
212-854-2948
stockwell@biology.columbia.edu


Personal Website

Disease Models: Cancer, Neurodegenerative Diseases

Stem Cell Categories: Cancer stem cells, ES and other embryonic stem cells

Model Organisms: Human, Rodent

Themes: Cancer, Neurodegeneration

The Stockwell lab sits at the interface of chemistry and biology and is systematically using small molecules to discover mechanisms underlying cellular processes. Our approach is interdisciplinary, combining chemical design and synthesis with genomics, biochemistry and cell biology, with the ultimate goal of revealing new basic biological mechanisms and disease pathophysiology.



Publications:

Hoffstrom BG, Kaplan A, Letso R, Schmid RS, Turmel GJ, Lo DC, Stockwell BR.
Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins. Nat Chem Biol. 6(12):900-6. (2010)

Varma H, Yamamoto A, Sarantos MR, Hughes RE, Stockwell BR.
Mutant Huntingtin Alters Cell Fate in Response to Microtubule Depolymerization via GEF-H1-RhoA-ERK Pathway. J Biol Chem. 285(48):37445-57. (2010)

Welsch ME, Snyder SA, Stockwell BR
Privileged scaffolds for library design and drug discovery Curr Opin Chem Biol 14(3):347-61. (2010)

Yang WS, Stockwell BR
Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem Biol. 234-45:15(3). (2008)

Yagoda N, von Rechenberg M, Zaganjor E, Bauer AJ, Yang WS, Fridman DJ, Wolpaw AJ, Smukste I, Peltier JM, Boniface JJ, Smith R, Lessnick SL, Sahasrabudhe S, Stockwell BR.
RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature 447(7146):865-69. (2007)

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