Title: Faculty & research interests

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FACULTY PROFILE

Alex  Dranovsky
Alex Dranovsky, MD, PhD
Assistant Professor of Clinical Psychiatry
Full Member

Department: Psychiatry

Kolb Annex 116
212-543-5115
ad722@columbia.edu


Disease Models: Psychological Disorders, Transplantation

Stem Cell Categories: Adult stem cells, Tissue progenitors

Model Organisms: Rodent

Themes: Brain, Stem Cell Biology

The ability of adult hippocampal stem cells to produce neurons is highly susceptible to psychosocial stress and enrichment. Dr. Dranovsky's lab is interested in examining how stress and enrichment affect stem cells, their lineages, and their contribution to hippocampal circuitry and function. Their current studies explore whether adding new stem cells to the adult hippocampus plays a physiological role for adaptation to stress. They are also using environmental interventions to unravel the molecular programs that make the stem cell niche permissive to producing more stem cells or more neurons. Deciphering these pathways will not only guide treatment development for stress-related disorders, but should also enlighten our prospects for regenerative medicine in the adult brain.



Publications:

Sahay A., Scobie K., Hill A., O’Carroll C.M., Kheirbek M., Burghardt N., Fenton A., Dranovsky A., Hen R.
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature 472:466-70. (2011)

Dranovsky A., Picchini A.M., Moadel T., Yamada A., Kimura S., Leonardo E.D., Hen R.
Experience dictates stem cell fate in the adult hippocampus. Neuron 70(5):908-23. (2011)

Dranovsky A. and Leonardo E.D.
Is there a role for adult-born neurons in adaptation to stress? Behavioural Brain Research PMID: 21621559 :. (2011)

Richardson-Jones, J.W., Craige, C.P., Guiard, B.P., Stephen, A.K., Metzger, K.L., Kung, H.F., Gardier, A.M., Dranovsky, A., David, D.J., Beck, S.G., Hen, R., and Leonardo, E.D.
5-HT1A autoreceptors determine vulnerability to stress and response to antidepressants. Neuron 65: 40-52. (2010)

Dranovsky A. and R. Hen
Hippocampal neurogenesis: Regulation by stress and antidepressants. Biol. Psychiatry 59:1136-1143. (2006)

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