Title: Faculty & research interests

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Andrea  Califano
Andrea Califano, PhD
Professor of Systems Biology
Founder Director, Columbia Initiative in Systems Biology
Director, Sulzberger Columbia Genome Center

Full Member

Department: Biochemistry and Molecular Biophysics
Institute of Cancer Genetics
Biomedical Informatics

HICCC, Room 911
212 851-5183
califano@c2b2.columbia.edu


Personal Website

Disease Models: Cancer, Drug Screening

Stem Cell Categories: Cancer stem cells, ES and other embryonic stem cells

Model Organisms: Human, Rodent

Themes: Cancer, Neurodegeneration

Dr. Califano's interests are broadly defined within the field of Systems Biology, with specific application to human malignancies. In particular his lab has spearheaded early efforts to assemble genome-wide, context-specific maps of molecular interactions in human cells, by integrating several reverse engineering approaches. These maps have shown significant promise in the rational elucidation of both physiological and pathological phenotypes. Over the last few years, his lab has assembled biochemically validated, genome-wide map of transcriptional and post-transcriptional interaction in several human cell contexts, including B cell, Breast Carcinoma, Glioma, and normal and tumor-related Stem Cells. These maps are being extensively used for the unbiased dissection of dysregulated pathways in related human malignancies. The Califano lab integrates the development of analytical methodologies with high-throughput experimental assays necessary for data generation and biochemical/biological validation.



Publications:

Lefebvre, C.,Rajbhandari, P., Alvarez, M.J., Bandaru, P., Lim, W.K.,Sato, M.,Wang, K.,Sumazin, P.,Kustagi, M., Bisikirska,B.C.,Basso, K.,Beltrao, P.,Krogan, N., Gautier, J.,Dalla-Favera, R.,Califano, A.
A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers. Mol Syst Biol. 6:377. (2010)

Carro, M.S.,Lim, W.K.,Alvarez, M.J.,bollo, R.J.,Zhao, X.,Snyder, E.Y.,Sulman, E.P., Anne, S.L.,Doetsch, F.,Colman, H.,Lasorella, A.,Aldape, K.,Califano, A.
The transcriptional network for mesenchymal transformation of brain tumors. Nature 463(7279):318-25. (2010)

Wang, K., Saito, M., bisikirska, B.C., Alvarez, M.J., Lim, W.K., Rajbhandari, P., Shen, Q., Nemenman, I., Basso, K.,margoline, A.A., Klein, U., Dalla-Favera, R., Califano, A.
Genome-wide identification of post-translational modulators of transcription factor activity in human B calls. Nat. Biotechnol. Sep, 27(9):829-39. (2009)

Mani, K.M., lefebvre, C., wang, K., Lim, W.K., Basso, K., Dall-Favera, R.,Califano, A.
A systems biology approach to prediction of oncogenes and molecular perturbation targets in B-cell lymphomas Mol. Syst. Biol. 4:169. (2008)

Basso, Katia, Margolin, Adam, A.,Stolovitzky, Gustavo, Klein, Ulf, dalla-Favera, Riccardo, & Califano, Andrea
Reverse engineering of regulatory networks in human B cells Nature Genetics 37:382-390. (2005)

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