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Matthew S. Hayden, M.D., Ph.D.

    Matthew S. Hayden, M.D., Ph.D.

  • Assistant Professor of Dermatology and Microbiology and Immunology
Dr. Hayden seeks to understand how cytokine signaling pathways regulate physiological inflammation and how corruption of these mechanisms contributes to pathology. Aberrant inflammation is now recognized as a contributing factor in a wide spectrum of diseases ranging from the diseases of metabolic syndrome, to neurodegenerative disease, to cutaneous autoimmunity. Even in dermatological malignancies, the role of inflammation as an etiological factor is increasingly appreciated. Although the contribution of specific cytokines has, in some cases, been established, the depth with which we comprehend the mechanisms leading to signaling dysregulation is generally inadequate. We are therefore using the tools of modern biochemistry and cell biology to investigate the architecture of relevant signaling pathways in order to identify new and more selective means of targeting signaling in inflammatory disease.

Additional research in the Hayden lab is currently focused on understanding signaling in response to the pro-inflammatory cytokine TNF, and other members of the TNF family. Numerous studies implicating the cytokine TNF in inflammatory diseases have resulted in the development and widespread use of anti-TNF agents, including in psoriasis and psoriatic arthritis. Despite remarkable success, current anti-TNF agents are hindered by biological and pharmacological shortcomings and alternative therapeutic approaches are needed. There are fundamental aspects of TNF biology that remain unclear. Our approach is to fully characterize the biochemistry and cell biology of TNFR1 signaling in order to meet unmet clinical needs and also improve our understanding of the signaling mechanisms that orchestrate the inflammatory response.

Board Certified
Education Ph.D,2010
Yale School of Medicine

Yale School of Medicine

Training Postdoctoral Research Scientist, 2010-2011
Department of Microbiology and Immunology, Columbia University Medical Center

Associate Research Scientist, 2011-
Department of Microbiology and Immunology, Columbia University Medical Center

Research Interests Molecular Immunology
Contact Information
Russ Berrie Medical Science Pavilion
1150 St. Nicholas Avenue Room 313A
New York, NY 10032
Tel: 212.851.4836
Fax: 212.851.4810


  • ©2009. Columbia University Medical Center, Department of Dermatology, New York, NY.