Dermatology Photo
researchers
David  Owens, PhD

    David Owens, PhD

  • Florence Irving Assistant Professor of Epithelial Cell Biology in Dermatology
Dr. Owen's overall focus is to determine the contributions of stem cells and differentiated cells to the development and progression of epidermal squamous cancer. Four specific areas of investigation include: i) defining the mechanism of how aberrant expression of the ?6?4 integrin receptor can disrupt TGF-? mediated growth inhibition thereby altering the epidermal tumor microenvironment and stimulating tumor cell progression and metastasis; ii) identifying and characterizing subpopulations of clonogenic, multipotent stem cells in normal and neoplastic epidermis with differing malignant potentials in order to determine the significance of target cell phenotype in the formation of epidermal squamous cancers, iii) defining the requirement for cell surface proteins, which normally regulate immune tolerance, in the homing and invasion of malignant epidermal keratinocytes, and iv) investigating the role of L-3-phosphoserine phosphatase in UV-induced keratinocyte apoptosis and carcinogenesis.
Board Certified
Education Doctor of Philosophy Toxicology and Carcinogenesis,1996
North Carolina State University
Raleigh, NC

Training Postdoctoral Fellow, Keratinocyte Laboratory - Integrins/Epidermal Cancer, 1997-2003
Cancer Research UK London
London, United Kingdom

Research Interests Squamous Cell Cancer and Its Modeling
Contact Information
Russ Berrie Medical Science Pavilion
1150 St Nicholas Avenue, Room 312A
New York, NY 10032
Tel: 212.851.4544
Fax: 212.851.4810
do2112@columbia.edu

 

  • ©2009. Columbia University Medical Center, Department of Dermatology, New York, NY.