Dermatology Photo
researchers
Bin  Zheng, Ph.D.

    Bin Zheng, Ph.D.

  • Assistant Professor of Skin Cancer Biology (in Dermatology)
  • and Pathology & Cell Biology (in the Institute of Cancer Genetics)
Our laboratory is interested in deciphering the molecular mechanisms of metabolic signaling in cancer, with special emphasis on melanoma, and translating these basic research findings into potential personalized targeted therapies. The focus of our current research is on the LKB1-AMPK signaling pathway, which couples energy metabolism to cell growth, proliferation and survival. AMPK (AMP-activated protein kinase) is a Ser/Thr protein kinase that serves as a cellular energy sensor. The activity of AMPK is regulated by the AMP/ATP ratio and by upstream activating kinases, including the tumor suppressor LKB1. Metformin, one of the most prescribed drugs for treating type II diabetes, has been shown to target the LKB1-AMPK pathway and is currently being evaluated for the treatment of cancer in clinical trials. Understanding the complex LKB1-AMPK signaling circuitries underlying tumorigenesis will contribute to the development of effective therapeutic strategies.
Board Certified
Education Ph.D.,2002
University of California San Diego


Training Postdoctoral Fellow, 2003-2008
Beth Israel Deaconess Medical Center, Harvard Medical School


Instructor, 2008-2010
Beth Israel Deaconess Medical Center, Harvard Medical School


Research Interests Signal Transduction and Cancer Cell metabolism in Melanoma
Contact Information
Irving Cancer Research Center
1130 St. Nicholas Ave, Rm 402B
New York City, NY 10032
Tel: 212.851.4791
Fax: 212.851.5256

 

  • ©2009. Columbia University Medical Center, Department of Dermatology, New York, NY.